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Amyloid

amyloid beta protein

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Basic description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current within the vascular amyloid deposits. Aβ40 includes of C-terminal membrane insertion area. It reveals structural transition from random coil to a α-helical construction in a water-micelle medium.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • within the temperature based mostly conformational research utilizing Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) research
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of sufferers with head trauma
  • as a part of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the most important constituents of senile plaques and neurofibrillary tangles that happen within the hippocampus, neocortex, and amygdala of sufferers with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) types cation based mostly ion channels.

Reconstitution

For maximal organic exercise, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Different Notes

Lyophilized from 0.1% TFA in H2O
amyloid
amyloid

Summary

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology within the human mind and the diploma of medical dementia. Current advances in our understanding of the event of amyloid pathology have helped resolve this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in numerous swimming pools, could also be extra intently associated to illness state. The composition of those swimming pools of Aβ displays completely different populations of amyloid deposits, and has particular correlates with the medical standing of the affected person. Imaging applied sciences, together with new amyloid imaging brokers based mostly on the chemical construction of histologic dyes, are actually making it doable to trace amyloid pathology together with illness development within the residing affected person. Apparently, these approaches point out that the Aβ deposited in AD is completely different from that present in animal fashions. Normally, deposited Aβ is extra simply cleared from the mind in animal fashions, and doesn’t present the identical bodily and biochemical traits because the amyloid present in AD. This raises necessary points concerning the event and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Beta Amyloid

MO20004 100 ug
EUR 246

Beta Amyloid

MO22142 100 ul
EUR 435

beta Amyloid 40 protein

30R-3013 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 42 protein

beta-Amyloid antibody

22965-100ul 100ul
EUR 390

beta Amyloid antibody

20R-AR011 250 ul
EUR 381
Description: Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-10624 1 ml
EUR 693
Description: Affinity purified Chicken polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-12571 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid Antibody

35506-100ul 100ul
EUR 390

beta Amyloid antibody

10R-7917 100 ug
EUR 322
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

10R-A124a 50 ug
EUR 1011
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

70R-AR020 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-BR019 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Beta Amyloid antibody

70R-51450 100 ul
EUR 287
Description: Purified Polyclonal Beta Amyloid antibody

Amyloid beta-Protein (1-43)

5-00662 4 x 1mg Ask for price

Amyloid beta-Protein (20-29)

5-00663 4 x 5mg Ask for price

Amyloid beta-Protein (29-40)

5-00665 4 x 1mg Ask for price

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