One of many main present tendencies in most cancers immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved by antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such antibodies have revolutionized oncological remedy and proven a brand new method to battle most cancers. Further (unfavourable) immune checkpoints are additionally promising targets in most cancers remedy and there’s a demand for inhibitors for these molecules. Our research are targeted on BTLA/HVEM advanced, which inhibits T-cell proliferation and cytokine manufacturing and subsequently has nice potential as a brand new goal for most cancers remedy. The purpose of the offered research was the design and synthesis of compounds in a position to block BTLA/HVEM interactions.
For that objective, the N-terminal fragment of glycoprotein D (gD), which interacts with HVEM, was used. Based mostly on the crystal construction of the gD/HVEM advanced and MM/GBSA evaluation carried out on it, a number of peptides had been designed and synthesized as potential inhibitors of the BTLA/HVEM interplay. Affinity checks, ELISA checks, and cellular-based reporter assays had been carried out on these compounds to verify their capacity to bind to HVEM and to inhibit BTLA/HVEM advanced formation. For main peptides candidates, all-atom and subsequent docking simulations with a coarse-grained pressure area had been carried out to find out their binding modes.
To additional consider their potential as drug candidates, their stability in plasma and their cytotoxicity results on PBMCs had been assessed. Our information point out that the peptide gD(1-36)(Okay10C-T29C) is the greatest candidate as a future drug. It interacts with HVEM protein, blocks the BTLA/HVEM interplay, and is unhazardous to cells. The current examine gives a brand new perspective on the event of BTLA/HVEM inhibitors that disrupt protein interactions.
Outcomes of an early security evaluation of a examine of the mixture of pembrolizumab and pelvic chemoradiation in regionally superior cervical most cancers
Background: Immune checkpoint inhibitors are being thought-about for regionally superior cervical most cancers (LACC) along with standard-of-care pelvic chemoradiation (CRT). Nevertheless, the protection of the mixture and its optimum schedule are unknown. Defining the protection of the mixture is a major goal of a examine inspecting concurrent and sequential schedules. This text presents a security evaluation that was totally accrued and met reporting necessities.
Strategies: Pembrolizumab was given after CRT (arm 1) or throughout CRT (arm 2) in keeping with a randomized part 2 design. Sufferers who had been 18 years previous or older and had LACC (levels IB-IVA in keeping with the 2009 Worldwide Federation of Gynecology and Obstetrics system) had been randomized 1:1 to the remedy regimens. The CRT was equivalent within the 2 arms. Pembrolizumab was administered each three weeks for three doses; no upkeep was allowed. All sufferers receiving any remedy had been evaluated for security. Security assessments included the incidence and severity of adversarial occasions (AEs) and the prevalence of protocol-defined dose-limiting toxicity (DLT) by 30 days after the final pembrolizumab infusion.
Outcomes: As of August 2019, 52 of the 88 deliberate sufferers had accomplished remedy and had been evaluable for toxicity. Remedy-related grade 2 or increased toxicity was skilled by 88%; 11 had at the least 1 grade Four AE, and one other 23 had at the least 1 grade three AE. Grade 1 or increased diarrhea was reported in 34 sufferers, and there was no distinction between arms. Two sufferers skilled three DLTs. Most sufferers accomplished cisplatin (100% in arm 1 vs 82% in arm 2); 83% in each arms accomplished all pembrolizumab.
Conclusions: Preliminary outcomes help the protection and feasibility of including pembrolizumab to pelvic CRT concurrently or sequentially.
Lay abstract: Pembrolizumab is a humanized antibody towards programmed cell demise protein 1 that’s utilized in most cancers immunotherapy. Preliminary information counsel that pembrolizumab may be safely mixed with chemotherapy and pelvic radiation within the remedy of regionally superior cervical most cancers. Future research of the addition of immunotherapy to conventional chemoradiation are deliberate to find out the greatest method to ship the remedy and whether or not any enchancment is seen with the addition of immunotherapy to conventional remedy.
Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Dimension of Cost Patches on Complementarity-Figuring out Areas
A localized optimistic cost on IgG (known as a “cost patch”) exhibits an adversarial impact on pharmacokinetics (PK), so it will appear to be greatest follow to keep away from cost patches through the discovery stage and intently monitor cost interactions through the growth course of. In sure circumstances, nevertheless, cost patches are required for goal binding, through which case fully eradicating cost patches just isn’t possible.
Due to this fact, quantitative measurement of a cost patch and its impression on PK is important to the success of therapeutic antibody growth. On this article, we generated mutations of a recombinant human antibody (known as mAb1) with disrupted cost patches to research how cost patches on IgG antibodies impression each target-binding affinity and PK-related elements. We conclude that you will need to modulate the dimensions of the cost patch to be able to steadiness target-binding affinity and PK.
HO-1 ELISA Kit |
abx259907-96well |
Abbexa |
96 well |
EUR 926 |
|
HO-1 ELISA Kit |
SKT-111-480 |
Stressmarq |
5 plates of 96 wells |
EUR 2277 |
|
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat |
HO-1 ELISA Kit |
SKT-111-96 |
Stressmarq |
1 plate of 96 wells |
EUR 585 |
|
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat |
HO-1 ELISA Kit| Rat Heme Oxygenase 1 ELISA Kit |
EF017799 |
Lifescience Market |
96 Tests |
EUR 689 |
HO-1 ELISA Kit| Mouse Heme Oxygenase 1 ELISA Kit |
EF013687 |
Lifescience Market |
96 Tests |
EUR 689 |
Human HO-1/HMOX1 PicoKine ELISA Kit |
EK0888 |
BosterBio |
96 wells |
EUR 425 |
Description: For quantitative detection of human HO-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
ELISA kit for Human HO-1/HMOX1 |
EK5397 |
SAB |
96 tests |
EUR 553 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human HO-1/HMOX1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Mouse heme oxygenase 1(HO-1)ELISA Kit |
GA-E0279MS-48T |
GenAsia Biotech |
48T |
EUR 336 |
Mouse heme oxygenase 1(HO-1)ELISA Kit |
GA-E0279MS-96T |
GenAsia Biotech |
96T |
EUR 534 |
Rat heme oxygenase 1(HO-1)ELISA Kit |
GA-E0684RT-48T |
GenAsia Biotech |
48T |
EUR 317 |
Rat heme oxygenase 1(HO-1)ELISA Kit |
GA-E0684RT-96T |
GenAsia Biotech |
96T |
EUR 496 |
Human heme oxygenase 1(HO-1)ELISA Kit |
GA-E0949HM-48T |
GenAsia Biotech |
48T |
EUR 289 |
Human heme oxygenase 1(HO-1)ELISA Kit |
GA-E0949HM-96T |
GenAsia Biotech |
96T |
EUR 466 |
Human heme oxygenase 1,HO-1 ELISA Kit |
201-12-0933 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Mouse HO-1(Heme Oxygenase 1) ELISA Kit |
EM1128 |
FN Test |
96T |
EUR 524.1 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml |
Rat HO-1(Heme Oxygenase 1) ELISA Kit |
ER1041 |
FN Test |
96T |
EUR 524.1 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml |
Human heme oxygenase 1, HO-1 ELISA Kit |
CSB-E08266h-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Human heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human heme oxygenase 1, HO-1 ELISA Kit |
1-CSB-E08266h |
Cusabio |
-
EUR 900.00
-
EUR 5476.00
-
EUR 2900.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat heme oxygenase 1, HO-1 ELISA Kit |
CSB-E08267r-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat heme oxygenase 1, HO-1 ELISA Kit |
1-CSB-E08267r |
Cusabio |
-
EUR 967.00
-
EUR 5925.00
-
EUR 3134.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse heme oxygenase 1, HO-1 ELISA Kit |
CSB-E08268m-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse heme oxygenase 1, HO-1 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse heme oxygenase 1, HO-1 ELISA Kit |
1-CSB-E08268m |
Cusabio |
-
EUR 946.00
-
EUR 5782.00
-
EUR 3060.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse heme oxygenase 1, HO-1 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat heme oxygenase 1,HO-1 ELISA Kit |
CN-01878R1 |
ChemNorm |
96T |
EUR 457 |
Rat heme oxygenase 1,HO-1 ELISA Kit |
CN-01878R2 |
ChemNorm |
48T |
EUR 306 |
Mouse heme oxygenase 1,HO-1 ELISA Kit |
CN-02756M1 |
ChemNorm |
96T |
EUR 457 |
Mouse heme oxygenase 1,HO-1 ELISA Kit |
CN-02756M2 |
ChemNorm |
48T |
EUR 306 |
Human heme oxygenase 1,HO-1 ELISA Kit |
CN-04663H1 |
ChemNorm |
96T |
EUR 464 |
Human heme oxygenase 1,HO-1 ELISA Kit |
CN-04663H2 |
ChemNorm |
48T |
EUR 313 |
HO-1 protein |
E20-80037 |
EnoGene |
20ug |
EUR 408 |
HO-1 Antibody |
AF5393 |
Affbiotech |
200ul |
EUR 304 |
Description: HO-1 Antibody detects endogenous levels of total HO-1. |
mRNAExpress mRNA Synthesis kit (5 reactions) |
MR-KIT-1 |
SBI |
5 reactions |
EUR 1152 |
|
PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
PIN320A-KIT |
SBI |
1 Kit |
EUR 4941 |
|
PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
PIN340iPS-KIT |
SBI |
1 Kit |
EUR 4941 |
|
HO-1 Rabbit pAb |
A11102-100ul |
Abclonal |
100 ul |
EUR 308 |
HO-1 Rabbit pAb |
A11102-200ul |
Abclonal |
200 ul |
EUR 459 |
HO-1 Rabbit pAb |
A11102-20ul |
Abclonal |
20 ul |
EUR 183 |
HO-1 Rabbit pAb |
A11102-50ul |
Abclonal |
50 ul |
EUR 223 |
HO-1 Rabbit pAb |
A11919-100ul |
Abclonal |
100 ul |
EUR 384 |
HO-1 Rabbit pAb |
A11919-200ul |
Abclonal |
200 ul |
Ask for price |
HO-1 Rabbit pAb |
A11919-20ul |
Abclonal |
20 ul |
Ask for price |
HO-1 Rabbit pAb |
A11919-50ul |
Abclonal |
50 ul |
EUR 265 |
HO-1 Rabbit pAb |
A1346-100ul |
Abclonal |
100 ul |
EUR 308 |
HO-1 Rabbit pAb |
A1346-200ul |
Abclonal |
200 ul |
EUR 459 |
HO-1 Rabbit pAb |
A1346-20ul |
Abclonal |
20 ul |
EUR 183 |
HO-1 Rabbit pAb |
A1346-50ul |
Abclonal |
50 ul |
EUR 223 |
Rat HO-1 Protein |
SPR-315A |
Stressmarq |
0.05 mg |
EUR 261 |
|
Description: His tagged recombinant rat HO-1 Protein expressed in E. coli for WB, SDS-PAGE. The biological activity of this protein has not yet been tested. |
Rat HO-1 Protein |
SPR-315B |
Stressmarq |
0.1 mg |
EUR 418 |
|
Description: His tagged recombinant rat HO-1 Protein expressed in E. coli for WB, SDS-PAGE. The biological activity of this protein has not yet been tested. |
Rat HO-1 Protein |
SPR-315C |
Stressmarq |
2x0.1 mg |
EUR 564 |
|
Description: His tagged recombinant rat HO-1 Protein expressed in E. coli for WB, SDS-PAGE. The biological activity of this protein has not yet been tested. |
HO-1 Polyclonal Antibody |
27573-100ul |
SAB |
100ul |
EUR 252 |
HO-1 Polyclonal Antibody |
27573-50ul |
SAB |
50ul |
EUR 187 |
HO-1 Polyclonal Antibody |
27513-100ul |
SAB |
100ul |
EUR 252 |
HO-1 Polyclonal Antibody |
27513-50ul |
SAB |
50ul |
EUR 187 |
HO-1 Blocking Peptide |
AF5393-BP |
Affbiotech |
1mg |
EUR 195 |
ExoAb Antibody Kit (CD9, CD63, CD81, Hsp70 antibodies, rabbit anti-human) with goat anti-rabbit HRP secondary antibody |
EXOAB-KIT-1 |
SBI |
25 ul each |
EUR 627 |
|
T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents) |
CAS510A-KIT |
SBI |
1 Kit |
EUR 805 |
|
Mouse Heme Oxygenase 1 (HO-1) CLIA Kit |
abx195765-96tests |
Abbexa |
96 tests |
EUR 825 |
|
Rat Heme Oxygenase 1 (HO-1) CLIA Kit |
abx195766-96tests |
Abbexa |
96 tests |
EUR 825 |
|
PinPoint-FC System for Platform Cell Line Generation & Retargeting (includes PIN300A-1, FC200PA-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
PIN300A-KIT |
SBI |
1 Kit |
EUR 2798 |
|
Frit Kit |
FRIT-KIT |
Next Advance |
1each |
EUR 124 |
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool. |
PinPoint-HR System for Platform Cell Line Generation & Retargeting (includes PIN400A-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
PIN400A-KIT |
SBI |
1 Kit |
EUR 2798 |
|
Brms1 ELISA Kit| Mouse Breast cancer metastasis-suppressor 1 ho |
EF014335 |
Lifescience Market |
96 Tests |
EUR 689 |
PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, GE601A-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
PIN410A-KIT |
SBI |
1 Kit |
EUR 4335 |
|
PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, CAS601A-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
PIN412A-KIT |
SBI |
1 Kit |
EUR 4335 |
|
Column Packing Kit |
PACK-KIT |
Next Advance |
1pack |
EUR 1035 |
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar. |
HO-3867 |
B4970-25 |
ApexBio |
25 mg |
EUR 534 |
Description: HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis. |
HO-3867 |
B4970-5 |
ApexBio |
5 mg |
EUR 212 |
Description: HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis. |
HO-3867 |
B4970-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 293 |
Description: HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis. |
HO-2 ELISA Kit| Rat heme oxygenase 2 ELISA Kit |
EF017800 |
Lifescience Market |
96 Tests |
EUR 689 |
AXYPET STARTER KIT 1 AP-20, AP-200 & AP-1000 WITH ADDITIONAL FREE RACKS OF AXYGEN PIPETTE TIPS |
AP-STR-KIT-1 |
CORNING |
1/pk |
EUR 355 |
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller |
PCR Mycoplasma Detection Kit |
M034-Kit |
TOKU-E |
Kit |
EUR 266 |
Heme Oxygenase 1 (HO-1) Antibody |
abx448465-100ug |
Abbexa |
100 ug |
EUR 523 |
|
Heme Oxygenase 1 (HO-1) Antibody |
20-abx444865 |
Abbexa |
|
|
|
Heme Oxygenase 1 (HO-1) Antibody |
abx444939-100ug |
Abbexa |
100 ug |
EUR 523 |
|
Heme Oxygenase 1 (HO-1) Antibody |
20-abx445136 |
Abbexa |
|
|
|
Heme Oxygenase 1(HO-1) Antibody |
48715-100ul |
SAB |
100ul |
EUR 333 |
Heme Oxygenase 1(HO-1) Antibody |
48715-50ul |
SAB |
50ul |
EUR 239 |
Anti-HO-1 Monoclonal Antibody |
M00253-2 |
BosterBio |
100ug |
EUR 397 |
Description: Mouse Monoclonal HO-1 Antibody. Validated in ELISA, IP, IF, IHC, WB and tested in Human, Mouse, Rat. |
Rat Natural HO-1 Protein |
SPR-318A |
Stressmarq |
0.05 mg |
EUR 506 |
|
Description: Untagged Natural rat HO-1 Protein expressed in Native for WB, SDS-PAGE. The biological activity of this protein has not yet been tested. |
Rat Natural HO-1 Protein |
SPR-318B |
Stressmarq |
0.1 mg |
EUR 746 |
|
Description: Untagged Natural rat HO-1 Protein expressed in Native for WB, SDS-PAGE. The biological activity of this protein has not yet been tested. |
Rat Natural HO-1 Protein |
SPR-318C |
Stressmarq |
2x0.1 mg |
EUR 1260 |
|
Description: Untagged Natural rat HO-1 Protein expressed in Native for WB, SDS-PAGE. The biological activity of this protein has not yet been tested. |
Polyclonal HMOX1 / HO-1 Antibody |
APR07773G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HMOX1 / HO-1 . This antibody is tested and proven to work in the following applications: |
Polyclonal HMOX1 / HO-1 Antibody |
APR07774G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HMOX1 / HO-1 . This antibody is tested and proven to work in the following applications: |
Polyclonal HMOX1 / HO-1 Antibody |
APR07775G |
Leading Biology |
0.05mg |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HMOX1 / HO-1 . This antibody is tested and proven to work in the following applications: |
Antibody for Human HO-1 |
SPC-112C |
Stressmarq |
0.025mg |
EUR 174 |
|
Description: A polyclonal antibody for HO-1 from Human | Mouse | Rat | Dog. The antibody is produced in rabbit after immunization with human heme-oxygenase (HO-1) synthetic multiple antigenic peptide. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100). This HO-1 antibody is unconjugated. |
Antibody for Human HO-1 |
SPC-112D |
Stressmarq |
0.1mg |
EUR 305 |
|
Description: A polyclonal antibody for HO-1 from Human | Mouse | Rat | Dog. The antibody is produced in rabbit after immunization with human heme-oxygenase (HO-1) synthetic multiple antigenic peptide. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100). This HO-1 antibody is unconjugated. |
Antibody for Human HO-1 |
SPC-112D-A390 |
Stressmarq |
0.1mg |
EUR 352 |
|
Description: A polyclonal antibody for HO-1 from Human | Mouse | Rat | Dog. The antibody is produced in rabbit after immunization with human heme-oxygenase (HO-1) synthetic multiple antigenic peptide. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100). This HO-1 antibody is conjugated to ATTO 390. |
Antibody for Human HO-1 |
SPC-112D-A488 |
Stressmarq |
0.1mg |
EUR 351 |
|
Description: A polyclonal antibody for HO-1 from Human | Mouse | Rat | Dog. The antibody is produced in rabbit after immunization with human heme-oxygenase (HO-1) synthetic multiple antigenic peptide. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100). This HO-1 antibody is conjugated to ATTO 488. |
Antibody for Human HO-1 |
SPC-112D-A565 |
Stressmarq |
0.1mg |
EUR 351 |
|
Description: A polyclonal antibody for HO-1 from Human | Mouse | Rat | Dog. The antibody is produced in rabbit after immunization with human heme-oxygenase (HO-1) synthetic multiple antigenic peptide. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100). This HO-1 antibody is conjugated to ATTO 565. |
Antibody for Human HO-1 |
SPC-112D-A594 |
Stressmarq |
0.1mg |
EUR 351 |
|
Description: A polyclonal antibody for HO-1 from Human | Mouse | Rat | Dog. The antibody is produced in rabbit after immunization with human heme-oxygenase (HO-1) synthetic multiple antigenic peptide. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100). This HO-1 antibody is conjugated to ATTO 594. |
Avelumab, an antiprogrammed demise ligand-1 antibody, is authorized as a monotherapy for remedy of metastatic Merkel cell carcinoma and superior urothelial carcinoma, and together with axitinib for superior renal cell carcinoma. We report the efficacy and security of first-line avelumab in superior non-small cell lung most cancers (NSCLC).