Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation-Design, Synthesis, and Cellular Studies

One of many main present tendencies in most cancers immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved by antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such antibodies have revolutionized oncological remedy and proven a brand new method to battle most cancers. Further (unfavourable) immune checkpoints are additionally promising targets in most cancers remedy and there’s a demand for inhibitors for these molecules. Our research are targeted on BTLA/HVEM advanced, which inhibits T-cell proliferation and cytokine manufacturing and subsequently has nice potential as a brand new goal for most cancers remedy. The purpose of the offered research was the design and synthesis of compounds in a position to block BTLA/HVEM interactions.

For that objective, the N-terminal fragment of glycoprotein D (gD), which interacts with HVEM, was used. Based mostly on the crystal construction of the gD/HVEM advanced and MM/GBSA evaluation carried out on it, a number of peptides had been designed and synthesized as potential inhibitors of the BTLA/HVEM interplay. Affinity checks, ELISA checks, and cellular-based reporter assays had been carried out on these compounds to verify their capacity to bind to HVEM and to inhibit BTLA/HVEM advanced formation. For main peptides candidates, all-atom and subsequent docking simulations with a coarse-grained pressure area had been carried out to find out their binding modes.

To additional consider their potential as drug candidates, their stability in plasma and their cytotoxicity results on PBMCs had been assessed. Our information point out that the peptide gD(1-36)(Okay10C-T29C) is the greatest candidate as a future drug. It interacts with HVEM protein, blocks the BTLA/HVEM interplay, and is unhazardous to cells. The current examine gives a brand new perspective on the event of BTLA/HVEM inhibitors that disrupt protein interactions.

Outcomes of an early security evaluation of a examine of the mixture of pembrolizumab and pelvic chemoradiation in regionally superior cervical most cancers

Background: Immune checkpoint inhibitors are being thought-about for regionally superior cervical most cancers (LACC) along with standard-of-care pelvic chemoradiation (CRT). Nevertheless, the protection of the mixture and its optimum schedule are unknown. Defining the protection of the mixture is a major goal of a examine inspecting concurrent and sequential schedules. This text presents a security evaluation that was totally accrued and met reporting necessities.

Strategies: Pembrolizumab was given after CRT (arm 1) or throughout CRT (arm 2) in keeping with a randomized part 2 design. Sufferers who had been 18 years previous or older and had LACC (levels IB-IVA in keeping with the 2009 Worldwide Federation of Gynecology and Obstetrics system) had been randomized 1:1 to the remedy regimens. The CRT was equivalent within the 2 arms. Pembrolizumab was administered each three weeks for three doses; no upkeep was allowed. All sufferers receiving any remedy had been evaluated for security. Security assessments included the incidence and severity of adversarial occasions (AEs) and the prevalence of protocol-defined dose-limiting toxicity (DLT) by 30 days after the final pembrolizumab infusion.

Outcomes: As of August 2019, 52 of the 88 deliberate sufferers had accomplished remedy and had been evaluable for toxicity. Remedy-related grade 2 or increased toxicity was skilled by 88%; 11 had at the least 1 grade Four AE, and one other 23 had at the least 1 grade three AE. Grade 1 or increased diarrhea was reported in 34 sufferers, and there was no distinction between arms. Two sufferers skilled three DLTs. Most sufferers accomplished cisplatin (100% in arm 1 vs 82% in arm 2); 83% in each arms accomplished all pembrolizumab.

Conclusions: Preliminary outcomes help the protection and feasibility of including pembrolizumab to pelvic CRT concurrently or sequentially.

Lay abstract: Pembrolizumab is a humanized antibody towards programmed cell demise protein 1 that’s utilized in most cancers immunotherapy. Preliminary information counsel that pembrolizumab may be safely mixed with chemotherapy and pelvic radiation within the remedy of regionally superior cervical most cancers. Future research of the addition of immunotherapy to conventional chemoradiation are deliberate to find out the greatest method to ship the remedy and whether or not any enchancment is seen with the addition of immunotherapy to conventional remedy.

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Dimension of Cost Patches on Complementarity-Figuring out Areas

A localized optimistic cost on IgG (known as a “cost patch”) exhibits an adversarial impact on pharmacokinetics (PK), so it will appear to be greatest follow to keep away from cost patches through the discovery stage and intently monitor cost interactions through the growth course of. In sure circumstances, nevertheless, cost patches are required for goal binding, through which case fully eradicating cost patches just isn’t possible.

Due to this fact, quantitative measurement of a cost patch and its impression on PK is important to the success of therapeutic antibody growth. On this article, we generated mutations of a recombinant human antibody (known as mAb1) with disrupted cost patches to research how cost patches on IgG antibodies impression each target-binding affinity and PK-related elements. We conclude that you will need to modulate the dimensions of the cost patch to be able to steadiness target-binding affinity and PK.

HO-1 ELISA Kit
SKT-111-96 1 plate of 96 wells
EUR 702
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HO-1 ELISA Kit| Rat Heme Oxygenase 1 ELISA Kit
EF017799 96 Tests
EUR 826.8

HO-1 ELISA Kit| Mouse Heme Oxygenase 1 ELISA Kit
EF013687 96 Tests
EUR 826.8

ELISA kit for Human HO-1/HMOX1
EK5397 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human HO-1/HMOX1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Rat heme oxygenase 1,HO-1 ELISA Kit
CN-01878R1 96T
EUR 548.4

Rat heme oxygenase 1,HO-1 ELISA Kit
CN-01878R2 48T
EUR 367.2

Rat heme oxygenase 1, HO-1 ELISA Kit
CSB-E08267r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat heme oxygenase 1, HO-1 ELISA Kit
1-CSB-E08267r
  • EUR 1160.40
  • EUR 7110.00
  • EUR 3760.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat HO-1(Heme Oxygenase 1) ELISA Kit
ER1041 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

Rat heme oxygenase 1(HO-1)ELISA Kit
GA-E0684RT-48T 48T
EUR 380.4

Rat heme oxygenase 1(HO-1)ELISA Kit
GA-E0684RT-96T 96T
EUR 595.2

Rat heme oxygenase 1(HO-1)ELISA Kit
QY-E10968 96T
EUR 433.2

Rat heme oxygenase 1,HO-1 ELISA Kit
YLA0269RA-48T 48T
EUR 465

Rat heme oxygenase 1,HO-1 ELISA Kit
YLA0269RA-96T 96T
EUR 600

Human heme oxygenase 1,HO-1 ELISA Kit
201-12-0933 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse heme oxygenase 1,HO-1 ELISA Kit
CN-02756M1 96T
EUR 548.4

Mouse heme oxygenase 1,HO-1 ELISA Kit
CN-02756M2 48T
EUR 367.2

Human heme oxygenase 1,HO-1 ELISA Kit
CN-04663H1 96T
EUR 556.8

Human heme oxygenase 1,HO-1 ELISA Kit
CN-04663H2 48T
EUR 375.6

Human heme oxygenase 1, HO-1 ELISA Kit
CSB-E08266h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human heme oxygenase 1, HO-1 ELISA Kit
1-CSB-E08266h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human heme oxygenase 1, HO-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse heme oxygenase 1, HO-1 ELISA Kit
CSB-E08268m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse heme oxygenase 1, HO-1 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse heme oxygenase 1, HO-1 ELISA Kit
1-CSB-E08268m
  • EUR 1135.20
  • EUR 6938.40
  • EUR 3672.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse heme oxygenase 1, HO-1 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human heme oxygenase 1(HO-1)ELISA Kit
GA-E0949HM-48T 48T
EUR 346.8

Human heme oxygenase 1(HO-1)ELISA Kit
GA-E0949HM-96T 96T
EUR 559.2

Mouse heme oxygenase 1(HO-1)ELISA Kit 　 　
GA-E0279MS-48T 48T
EUR 403.2

Mouse heme oxygenase 1(HO-1)ELISA Kit 　 　
GA-E0279MS-96T 96T
EUR 640.8

Mouse HO-1(Heme Oxygenase 1) ELISA Kit
EM1128 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Mouse heme oxygenase 1(HO-1)ELISA Kit
QY-E20729 96T
EUR 433.2

Human heme oxygenase 1(HO-1)ELISA Kit
QY-E00664 96T
EUR 433.2

Human heme oxygenase 1,HO-1 ELISA Kit
YLA0935HU-48T 48T
EUR 435

Human heme oxygenase 1,HO-1 ELISA Kit
YLA0935HU-96T 96T
EUR 562.5

Mouse heme oxygenase 1,HO-1 ELISA Kit 　 　
YLA0195MO-48T 48T
EUR 465

Mouse heme oxygenase 1,HO-1 ELISA Kit 　 　
YLA0195MO-96T 96T
EUR 600

Human HO-1/HMOX1 PicoKine ELISA Kit
EK0888 96 wells
EUR 510
Description: For quantitative detection of human HO-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Sheep Heparin-binding growth factor 1(HO-1)ELISA Kit
YLA0056SH-48T 48T
EUR 540

Sheep Heparin-binding growth factor 1(HO-1)ELISA Kit
YLA0056SH-96T 96T
EUR 645

HO-2 ELISA Kit| Rat heme oxygenase 2 ELISA Kit
EF017800 96 Tests
EUR 826.8

Brms1 ELISA Kit| Mouse Breast cancer metastasis-suppressor 1 ho
EF014335 96 Tests
EUR 826.8

Rat heme oxygenase 2,HO-2 ELISA Kit
CN-01837R1 96T
EUR 556.8

Rat heme oxygenase 2,HO-3 ELISA Kit
CN-01837R2 48T
EUR 375.6

Rat HO-2(heme oxygenase 2) ELISA Kit
ER1042 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.938mU/ml

Rat heme oxygenase 2(HO-2)ELISA Kit
GA-E0685RT-48T 48T
EUR 380.4

Rat heme oxygenase 2(HO-2)ELISA Kit
GA-E0685RT-96T 96T
EUR 595.2

Rat heme oxygenase 2(HO-2)ELISA Kit
QY-E10967 96T
EUR 433.2

Rat heme oxygenase 2,HO-2 ELISA Kit
YLA0449RA-48T 48T
EUR 465

Rat heme oxygenase 2,HO-2 ELISA Kit
YLA0449RA-96T 96T
EUR 600

Human heme oxygenase 2,HO-2 ELISA Kit
201-12-0894 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse heme oxygenase 2,HO-2 ELISA Kit
CN-02714M1 96T
EUR 549.6

Mouse heme oxygenase 2,HO-2 ELISA Kit
CN-02714M2 48T
EUR 368.4

Human heme oxygenase 2,HO-2 ELISA Kit
CN-04658H1 96T
EUR 529.2

Human heme oxygenase 2,HO-2 ELISA Kit
CN-04658H2 48T
EUR 349.2

Human heme oxygenase 2, HO-2 ELISA Kit
CSB-E08408h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human heme oxygenase 2, HO-2 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human heme oxygenase 2, HO-2 ELISA Kit
1-CSB-E08408h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human heme oxygenase 2, HO-2 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human heme oxygenase 2(HO-2)ELISA Kit
GA-E0910HM-48T 48T
EUR 346.8

Human heme oxygenase 2(HO-2)ELISA Kit
GA-E0910HM-96T 96T
EUR 559.2

Mouse heme oxygenase 2(HO-2)ELISA Kit
GA-E0394MS-48T 48T
EUR 403.2

Mouse heme oxygenase 2(HO-2)ELISA Kit
GA-E0394MS-96T 96T
EUR 640.8

Mouse heme oxygenase 2(HO-2)ELISA Kit
QY-E20730 96T
EUR 433.2

Human heme oxygenase 2(HO-2)ELISA Kit
QY-E00663 96T
EUR 433.2

Mouse heme oxygenase 2,HO-2 ELISA Kit
YLA0805MO-48T 48T
EUR 465

Mouse heme oxygenase 2,HO-2 ELISA Kit
YLA0805MO-96T 96T
EUR 600

Human heme oxygenase 2,HO-2 ELISA Kit
YLA0842HU-48T 48T
EUR 435

Human heme oxygenase 2,HO-2 ELISA Kit
YLA0842HU-96T 96T
EUR 562.5

HO-2 ELISA Kit| Mouse Heme Oxygenase 2, Decycling ELISA Kit
EF013688 96 Tests
EUR 826.8

Mouse HO-2(Heme Oxygenase 2, Decycling) ELISA Kit
EM1129 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.375 ng/ml

Anti-HO-1 Monoclonal Antibody (HO-1-2)
M00253-1 1mg
EUR 476.4
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat.

HO-1 Antibody
AF5393 200ul
EUR 420

HO- 1 Antibody
ABF5393 100 ug
EUR 525.6

HO-1 Antibody
DF6391 200ul
EUR 420

HO-1 protein
E20-80037 20ug
EUR 489.6

HO-1 Antibody
R31625 100 ug
EUR 356.15
Description: Heme oxygenase (decycling) 1, also known as HO-1, is an essential enzyme in heme catabolism. HO-1 belongs to the heme oxygenase family. The HMOX1 gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748. HO-1, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. HO-1 activity is induced by its substrate heme and by various nonheme substances.

Smad1/MADH1 ELISA Kit| Rabbit Mothers Against Decapentaplegic Ho
EF016874 96 Tests
EUR 826.8

HO-1-IN-1
HY-111798 10mg
EUR 680.4

Rtf1 ELISA Kit| Mouse RNA polymerase-associated protein RTF1 ho
EF016125 96 Tests
EUR 826.8

Rat Heme Oxygenase 1 (HO-1) CLIA Kit
abx195766-96tests 96 tests
EUR 990

Mouse Heme Oxygenase 1 (HO-1) CLIA Kit
abx195765-96tests 96 tests
EUR 990

HO-1 Polyclonal Antibody
27513-100ul 100ul
EUR 302.4

HO-1 Polyclonal Antibody
27513-50ul 50ul
EUR 224.4

HO-1 Polyclonal Antibody
27573-100ul 100ul
EUR 302.4

HO-1 Polyclonal Antibody
27573-50ul 50ul
EUR 224.4

HO-1 Rabbit pAb
A11102-100ul 100 ul
EUR 369.6

HO-1 Rabbit pAb
A11102-200ul 200 ul
EUR 550.8

HO-1 Rabbit pAb
A11102-20ul 20 ul
EUR 219.6

HO-1 Rabbit pAb
A11102-50ul 50 ul
EUR 267.6

HO-1 Rabbit pAb
A11919-100ul 100 ul
EUR 460.8

HO-1 Rabbit pAb
A11919-200ul 200 ul Ask for price

HO-1 Rabbit pAb
A11919-20ul 20 ul Ask for price

HO-1 Rabbit pAb
A11919-50ul 50 ul
EUR 318

HO-1 Rabbit pAb
A1346-100ul 100 ul
EUR 369.6

HO-1 Rabbit pAb
A1346-200ul 200 ul
EUR 550.8

HO-1 Rabbit pAb
A1346-20ul 20 ul
EUR 219.6

HO-1 Rabbit pAb
A1346-50ul 50 ul
EUR 267.6

HO-1 Blocking Peptide
AF5393-BP 1mg
EUR 234

HO-1 Recombinant Protein
91-128 0.05 mg
EUR 651.3
Description: Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.

HO-1 Polyclonal Antibody
A70946
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

HO-1 Polyclonal Antibody
A70947
  • EUR 341.00
  • EUR 518.10
  • 50 ul
  • 100 ul

Rat HO-1 Protein
SPR-315A 0.05 mg
EUR 313.2
Description: His tagged recombinant rat HO-1 Protein expressed in E. coli for WB, SDS-PAGE. The biological activity of this protein has not yet been tested.

Rat HO-1 Protein
SPR-315B 0.1 mg
EUR 501.6
Description: His tagged recombinant rat HO-1 Protein expressed in E. coli for WB, SDS-PAGE. The biological activity of this protein has not yet been tested.

Rat HO-1 Protein
SPR-315C 2x0.1 mg
EUR 676.8
Description: His tagged recombinant rat HO-1 Protein expressed in E. coli for WB, SDS-PAGE. The biological activity of this protein has not yet been tested.

Human Heme Oxygenase (HO/HMOX1/HSP32) ELISA Kit, 96 tests, Quantitative
100-540-HO1 1 Kit
EUR 854.4

HO-1-IN-1 hydrochloride
HY-111798A 100mg
EUR 2952

HO-3867
B4970-25 25 mg
EUR 640.8
Description: HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis.

HO-3867
B4970-5 5 mg
EUR 254.4
Description: HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis.

HO-3867
B4970-5.1 10 mM (in 1mL DMSO)
EUR 351.6
Description: HO-3867 is a novel curcumin analog and a selective inhibitor of STAT3. [1]STAT3 (signal transducer and activator of transcription 3) belongs to the STAT protein family. It mediates various gene expressions for numerous cellular functions, including cell growth, division and apoptosis.

HO-3867
HY-100453 10mM/1mL
EUR 297.6

Heme Oxygenase 1 (HO-1) Antibody
20-abx444865
  • EUR 627.60
  • EUR 410.40
  • 100 ug
  • 25 ug

Heme Oxygenase 1 (HO-1) Antibody
abx444939-100ug 100 ug
EUR 627.6

Heme Oxygenase 1 (HO-1) Antibody
20-abx445136
  • EUR 560.40
  • EUR 360.00
  • 100 ug
  • 25 ug

Heme Oxygenase 1 (HO-1) Antibody
abx448465-100ug 100 ug
EUR 627.6

Heme Oxygenase 1(HO-1) Antibody
48715-100ul 100ul
EUR 399.6

Heme Oxygenase 1(HO-1) Antibody
48715-50ul 50ul
EUR 286.8

Heme Oxygenase 1 Antibody (HO-1)
R36412-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Heme oxygenase 1, HMOX1

Polyclonal HMOX1 / HO-1 Antibody
APR07773G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HMOX1 / HO-1 . This antibody is tested and proven to work in the following applications:

Polyclonal HMOX1 / HO-1 Antibody
APR07774G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HMOX1 / HO-1 . This antibody is tested and proven to work in the following applications:

Polyclonal HMOX1 / HO-1 Antibody
APR07775G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HMOX1 / HO-1 . This antibody is tested and proven to work in the following applications:

HO-1 Mouse Monoclonal Antibody
BF8020 100ul
EUR 420

HO-1 Polyclonal Conjugated Antibody
C27513 100ul
EUR 476.4

HO-1 Polyclonal Conjugated Antibody
C27573 100ul
EUR 476.4

Anti-HO-1 Monoclonal Antibody
M00253-2 100ug
EUR 476.4
Description: Mouse Monoclonal HO-1 Antibody. Validated in ELISA, IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Monoclonal antibody for HO-1
SMC-131C 0.025mg
EUR 248.4
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is not conjugated.

Monoclonal antibody for HO-1
SMC-131D 0.1mg
EUR 428.4
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is not conjugated.

Monoclonal antibody for HO-1
SMC-131D-A390 0.1mg
EUR 484.8
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 390.

Monoclonal antibody for HO-1
SMC-131D-A488 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 488.

Monoclonal antibody for HO-1
SMC-131D-A565 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 565.

Monoclonal antibody for HO-1
SMC-131D-A594 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 594.

Monoclonal antibody for HO-1
SMC-131D-A633 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 633.

Monoclonal antibody for HO-1
SMC-131D-A655 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 655.

Monoclonal antibody for HO-1
SMC-131D-A680 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 680.

Monoclonal antibody for HO-1
SMC-131D-A700 0.1mg
EUR 483.6
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with ATTO 700.

Monoclonal antibody for HO-1
SMC-131D-ALP 0.1mg
EUR 476.4
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with Alkaline Phosphatase.

Monoclonal antibody for HO-1
SMC-131D-APC 0.1mg
EUR 482.4
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with APC.

Monoclonal antibody for HO-1
SMC-131D-APCCY7 0.1mg
EUR 568.8
Description: A monoclonal antibody from clone 1F12-A6 against Human | Mouse | Rat | Bovine | Chicken HO-1. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human HO-1 synthetic peptide, amino acids 1-30. The antibody is tested and validated for WB, IHC, ICC/IF, IP, ELISA assays with the following recommended dilutions: WB (1:1000), IHC (1:100), ICC/IF (1:100). This MAb for HO-1 is conjugated with APC/Cy7.

Avelumab, an antiprogrammed demise ligand-1 antibody, is authorized as a monotherapy for remedy of metastatic Merkel cell carcinoma and superior urothelial carcinoma, and together with axitinib for superior renal cell carcinoma. We report the efficacy and security of first-line avelumab in superior non-small cell lung most cancers (NSCLC).

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