Hiding or snatching epitopes?

Antibodies forming a posh with antigen in vivo can dramatically change the antibody response to this antigen. In some conditions, the response shall be a 100-fold stronger than in animals immunized with antigen alone, and in different conditions, the response shall be utterly suppressed. IgG is understood to suppress the antibody response, for instance to erythrocytes, and that is used clinically in Rhesus prophylaxis.

 

Gentaurprices
Gentaurprices
anti-kallikrein 1
YF-PA12847 100 ug
EUR 403
Description: Rabbit polyclonal to kallikrein 1
anti-Kallikrein 2
YF-PA12848 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 2
anti-Kallikrein 2
YF-PA12849 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 2
anti-Kallikrein 2
YF-PA12850 100 ul
EUR 403
Description: Rabbit polyclonal to Kallikrein 2
anti-Kallikrein 2
YF-PA12851 100 ug
EUR 403
Description: Rabbit polyclonal to Kallikrein 2
anti-Kallikrein 7
YF-PA14076 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 7
anti-Kallikrein 7
YF-PA14077 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 7
anti-Kallikrein 7
YF-PA14078 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 7
anti-Kallikrein 7
YF-PA14079 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 7
anti-Kallikrein 7
YF-PA14080 100 ul
EUR 403
Description: Rabbit polyclonal to Kallikrein 7
anti-Kallikrein 7
YF-PA14081 100 ug
EUR 403
Description: Rabbit polyclonal to Kallikrein 7
anti-Kallikrein 10
YF-PA14084 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 10
anti-Kallikrein 10
YF-PA14085 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 10
anti-Kallikrein 10
YF-PA14086 100 ul
EUR 403
Description: Rabbit polyclonal to Kallikrein 10
anti-Kallikrein 9
YF-PA22915 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 9
anti-Kallikrein 9
YF-PA22916 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 9
anti-kallikrein 1
YF-PA24050 50 ul
EUR 334
Description: Mouse polyclonal to kallikrein 1
anti-Kallikrein 10
YF-PA24489 50 ul
EUR 334
Description: Mouse polyclonal to Kallikrein 10
anti-Kallikrein 11
YF-PA17361 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 11
anti-Kallikrein 8
YF-PA17510 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 8
anti-Kallikrein 8
YF-PA17511 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 8
anti-Kallikrein 8
YF-PA17512 100 ug
EUR 403
Description: Rabbit polyclonal to Kallikrein 8
anti-Kallikrein 5
YF-PA18096 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 5
anti-Kallikrein 13
YF-PA18203 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 13
anti-Kallikrein 14
YF-PA18716 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 14
anti-Kallikrein 14
YF-PA18717 50 ug
EUR 363
Description: Mouse polyclonal to Kallikrein 14
anti-Kallikrein 15
YF-PA19752 50 ul
EUR 363
Description: Mouse polyclonal to Kallikrein 15
anti-Kallikrein 5
YF-PA25938 50 ul
EUR 334
Description: Mouse polyclonal to Kallikrein 5
anti-Kallikrein 8
YF-PA25766 50 ul
EUR 334
Description: Mouse polyclonal to Kallikrein 8
Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280
anti- Kallikrein 1 antibody
FNab04456 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: kallikrein 1
  • Uniprot ID: P06870
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against Kallikrein 1
anti- Kallikrein 11 antibody
FNab04457 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: kallikrein-related peptidase 11
  • Uniprot ID: Q9UBX7
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against Kallikrein 11
anti- Kallikrein 2 antibody
FNab04458 100µg
EUR 548.75
  • Immunogen: kallikrein-related peptidase 2
  • Uniprot ID: P20151
  • Research Area: Cancer, Metabolism
Description: Antibody raised against Kallikrein 2
anti- Kallikrein 5 antibody
FNab04459 100µg
EUR 585
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: kallikrein-related peptidase 5
  • Uniprot ID: Q9Y337
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against Kallikrein 5
anti- Kallikrein 8 antibody
FNab04460 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: kallikrein-related peptidase 8
  • Uniprot ID: O60259
  • Research Area: Cancer, Metabolism, Developmental biology
Description: Antibody raised against Kallikrein 8
Anti-Kallikrein 1 antibody
PAab04456 100 ug
EUR 412
Anti-Kallikrein 11 antibody
PAab04457 100 ug
EUR 355
Anti-Kallikrein 2 antibody
PAab04458 100 ug
EUR 386
Anti-Kallikrein 5 antibody
PAab04459 100 ug
EUR 412
Anti-Kallikrein 8 antibody
PAab04460 100 ug
EUR 355
anti-Kallikrein 10 (1G8)
LF-MA10160 50 ug
EUR 363
Description: Mouse monoclonal to Kallikrein 10
anti-Kallikrein 8 (2F11)
LF-MA10161 100 ug
EUR 363
Description: Mouse monoclonal to Kallikrein 8
Anti-kallikrein 6 antibody
STJ73047 100 µg
EUR 359

The mechanism behind IgG-mediated immune suppression remains to be not understood. Right here, we are going to overview research carried out in experimental animal fashions and talk about the varied hypotheses put ahead to elucidate the profound suppressive impact of IgG. We conclude that an unique position for detrimental regulation of B cells by means of FcγRIIB, elevated clearance of erythrocytes from the circulation or complement-mediated lysis is unlikely.

Epitope masking, the place IgG hides the epitope from B cells, or trogocytosis, the place IgG removes the epitope from the erythrocyte, is appropriate with many observations. These two mechanisms usually are not mutually unique. Furthermore, it can’t be dominated out that clearance, together with different mechanisms, performs a job.

Antibody-mediated rejection with and with out donor-specific anti-human leucocyte antigen antibodies: efficiency of the peripheral blood 8-gene expression Assay

Background: Just lately a peripheral blood 8-gene expression assay was developed for non-invasive detection of antibody-mediated rejection (ABMR) after kidney transplantation. Its worth has not but been evaluated intimately in medical eventualities with totally different baseline illness likelihood [human leucocyte antigen donor-specific antibodies (HLA-DSA)-positive versus HLA-DSA-negative cases at the time of stable graft function versus graft dysfunction].
Strategies: Right here we investigated the diagnostic accuracy of the 8-gene expression assay for histology of ABMR (ABMRh) with or with out HLA-DSA in a cross-sectional cohort examine of 387 blood samples with a concomitant graft biopsy.

anti-Cystatin C

YF-PA11157 100 ug
EUR 403
Description: Rabbit polyclonal to Cystatin C

anti-Cystatin S

YF-PA11158 50 ug
EUR 363
Description: Mouse polyclonal to Cystatin S

anti-Cystatin D

YF-PA11159 50 ug
EUR 363
Description: Mouse polyclonal to Cystatin D

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Anti-Cystatin C Antibody

A00961-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cystatin C Antibody (CST3) detection. Tested with WB in Human, Mouse, Rat, Monkey.

anti- Cystatin A antibody

FNab02179 100µg
EUR 505.25
  • Immunogen: cystatin A(stefin A)
  • Uniprot ID: P01040
  • Research Area: Metabolism
Description: Antibody raised against Cystatin A

anti- Cystatin B antibody

FNab02180 100µg
EUR 505.25
  • Immunogen: cystatin B(stefin B)
  • Uniprot ID: P04080
  • Research Area: Metabolism
Description: Antibody raised against Cystatin B

anti- Cystatin C antibody

FNab02181 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:50-1:200
  • IF: 1:20-1:200
  • Immunogen: cystatin C
  • Uniprot ID: P01034
  • Gene ID: 1471
  • Research Area: Stem Cells, Cancer, Metabolism
Description: Antibody raised against Cystatin C

anti- Cystatin F antibody

FNab02182 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: cystatin F(leukocystatin)
  • Uniprot ID: O76096
  • Research Area: Metabolism
Description: Antibody raised against Cystatin F

Anti-Cystatin A antibody

PAab02179 100 ug
EUR 355

Anti-Cystatin B antibody

PAab02180 100 ug
EUR 355

Anti-Cystatin C antibody

PAab02181 100 ug
EUR 355

Anti-Cystatin F antibody

PAab02182 100 ug
EUR 386

Anti-Cystatin 11 antibody

STJ92612 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin 11.

Anti-Cystatin 8 antibody

STJ92613 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin 8.

Anti-Cystatin A antibody

STJ92614 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin A.

Anti-Cystatin B antibody

STJ92615 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin B.

Anti-Cystatin C antibody

STJ92616 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin C.

Anti-Cystatin L1 antibody

STJ92618 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin L1.

Anti-Cystatin SA antibody

STJ92619 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin SA.

Anti-Cystatin SN antibody

STJ92620 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin SN.

Anti-Cystatin C antibody

STJ97732 200 µl
EUR 197
Description: Cystatin C is a protein encoded by the CST3 gene which is approximately 15,7 kDa. Cystatin C is secreted into the extracellular space. It is involved in the innate immune system, salivary secretion, neuroscience and plaque formation. This protein falls under the cystatin superfamily. It is the most abundant extracellular inhibitor of cysteine proteases and is thought to serve an important physiological role as a local regulator of this enzyme activity. Cystatin C is expressed in the nervous system, blood, kidney, saliva and muscle. Mutations in the CST3 gene may result in Creutzfeldt-Jakob disease. STJ97732 was developed from clone 7F11 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of CST3.

Anti-Cystatin C antibody

STJ97734 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ97735 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ97736 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ97737 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ97981 100 µl
EUR 234
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin A antibody

STJ98707 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin A.

Anti-Cystatin B antibody

STJ98972 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin B.

Anti-Cystatin C antibody

STJ99193 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ99194 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ99195 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C antibody

STJ99196 200 µl
EUR 197
Description: Mouse monoclonal to Cystatin C.

Anti-Cystatin C (2G4)

YF-MA12586 100 ug
EUR 363
Description: Mouse monoclonal to Cystatin C

Anti-Cystatin C (1H4)

YF-MA12587 100 ug
EUR 363
Description: Mouse monoclonal to Cystatin C

Anti-Cystatin C (3D10)

YF-MA12588 100 ug
EUR 363
Description: Mouse monoclonal to Cystatin C

Anti-Cystatin A (1A11)

YF-MA12590 100 ug
EUR 363
Description: Mouse monoclonal to Cystatin A

Anti-Cystatin A (4D8)

YF-MA12591 100 ug
EUR 363
Description: Mouse monoclonal to Cystatin A

Anti-CST2/Cystatin Sa Antibody

A08736 100ul
EUR 397
Description: Rabbit Polyclonal CST2/Cystatin Sa Antibody. Validated in IHC and tested in Human.

Anti-CST8/Cystatin 8 Antibody

A11538-1 100ul
EUR 397
Description: Rabbit Polyclonal CST8/Cystatin 8 Antibody. Validated in IHC and tested in Human, Mouse.

Anti-Cystatin C Antibody (03A03)

A1377-100
EUR 403

Anti-Cystatin C Antibody (02H06)

A1378-100
EUR 403

Anti-CST1/Cystatin Sn Antibody

A05560 100ul
EUR 397
Description: Rabbit Polyclonal CST1/Cystatin Sn Antibody. Validated in IF, IHC and tested in Human.

Anti-Cystatin C/CST3 Antibody

A00961-2 100ug/vial
EUR 334

Anti-Cystatin C/Cst3 Antibody

A00961-3 100ug/vial
EUR 294

Anti-CST1/Cystatin Sn Antibody

A30630 100ul
EUR 397
Description: Rabbit Polyclonal CST1/Cystatin Sn Antibody. Validated in IF, IHC and tested in Human.

Anti-CST11/Cystatin 11 Antibody

A14842 100ul
EUR 397
Description: Rabbit Polyclonal CST11/Cystatin 11 Antibody. Validated in WB and tested in Human.

anti-Human Cystatin C Antibody

GCYS-80A 1 x 96 well plate
EUR 461

Anti-Cystatin C/CST3 Antibody

PA1369 100ug/vial
EUR 334

Anti-Cystatin A/CSTA Antibody

PA2105 100ug/vial
EUR 334

Anti-Cystatin A/CSTA Antibody

PB9564 100ug/vial
EUR 334

Anti-Cystatin E/M antibody

STJ92617 200 µl
EUR 197
Description: Rabbit polyclonal to Cystatin E/M.

Anti-Cystatin C 10005 antibody

STJ400208 1 mg
EUR 446

Anti-Cystatin C 10004 antibody

STJ400217 1 mg
EUR 446

Anti-Cystatin C 10002 antibody

STJ400218 1 mg
EUR 446

Anti-Cystatin C 10001 antibody

STJ400223 1 mg
EUR 446

Anti-Cystatin C 10003 antibody

STJ400224 1 mg
EUR 446

Anti-CST3 / cystatin C antibody

STJ71888 100 µg
EUR 359

Anti-Cystatin 3 (mouse) antibody

STJ70172 100 µg
EUR 359

Cystatin F (Cystatin F) Antibody

abx430905-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

Cystatin F (Cystatin F) Antibody

20-abx225127
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Cystatin F (Cystatin F) Antibody

abx232182-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Anti-Rat Cystatin C Monoclonal Antibody

A1023-100
EUR 370

Chicken Anti-Cystatin C Polyclonal antibody

CABT-RM275 1 mg
EUR 533

Anti-Cystatin C Rabbit Monoclonal Antibody

M00961 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cystatin C Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Cystatin B / Stefin B antibody

STJ70443 100 µg
EUR 359

Polyclonal Goat Anti-CST3 / cystatin C Antibody

APG00082G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CST3 / cystatin C . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Cystatin F / CMAP Antibody

APG00084G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Cystatin F / CMAP . This antibody is tested and proven to work in the following applications:

Mouse Anti Human Cystatin C Monoclonal Antibody

CABT-47549MH 0.2 mg
EUR 663

Mouse Anti Human Cystatin C Monoclonal Antibody

CABT-47551MH 0.2 mg
EUR 663

Anti-Cystatin C/CST3 Antibody (monoclonal, 4H8)

M00961-1 100ug/vial
EUR 334

Anti-Cystatin C/CST3 Antibody (monoclonal, 8H7)

M00961-3 100ug/vial
EUR 294

Anti-Cystatin C/CST3 Antibody (monoclonal, 8D1)

M00961-Biotin 50ug/vial
EUR 294
Outcomes: In sufferers with HLA-DSA (n = 64), the 8-gene expression assay discriminated DSA-positive ABMRh (DSAposABMRh) instances (n = 16) with good diagnostic efficiency . Additionally, in HLA-DSA-negative samples (n = 323), a clinically related diagnostic efficiency for DSAnegABMRh instances was discovered (n = 30) with an AUROC of 75.8% (95% CI 67.4-84.4). The 8-gene assay didn’t discriminate DSAposABMRh instances from DSAnegABMRh instances. There was a internet profit for medical decision-making when including the 8-gene expression assay to a medical mannequin consisting of estimated glomerular filtration price, proteinuria, HLA-DSA and age.
Conclusion: The 8-gene expression assay exhibits nice potential for implementation within the medical follow-up of high-risk HLA-DSA-positive sufferers and medical relevance in HLA-DSA-negative instances.